Photodisinfection Instantly Inactivates Host Inflammatory Factors

Dr. Richard Darveau and colleagues from the University of Washington have demonstrated that photodisinfection causes a potent inactivation of inflammatory factors produced by the host. The pictured chart shows that IL-1β treated with photodisinfection fails to produce an inflammatory response (respresented by E-Selectin expression levels). Similar results were shown for tumor necrosis factor alpha (TNF-α). Dr. Darveau’s group has also inactivated P. gingivalis protease using photodisinfection. This work builds on Professor Michael Wilson’s numerous publications and prior reports of efficacy against virulence factors like lipopolysaccharide (LPS).

The results of this study were published in the Journal of Periodontology.

Darveau R et al. Antimicrobial Photodynamic Therapy May Promote Periodontal Healing Through Multiple Mechanisms. Journal of Periodontology. 2009, Vol. 80, No. 11, Pages 1790-1798